GPCR LIGAND PEPTIDES AND A CONSERVED MOTIF THEIROF

摘要

The present invention relates to novel GPCR peptides and a screening method for identifying the same. The present invention provides the GPCR ligand peptides represented by a general formula 1 which is NH_2-Xa_1-Xa_2-Xa_3-Xa_4-Xa_5-Cys-His-Phe-Lys-Xa_6-Cys-Asn-Met-CONH_2. In the general formula 1, Xa_1 can be Gln, Asn, His, Ser, Thr, or Pro, Xa_2 can be Tyr or Arg, Xa_3 can be Met, Leu or Ile, Xa_4 can be Ser, Thr, Ala, or Gln, Xa_5 can be Pro, Leu, and Met, and Xa_6 can be Ile or Leu. In addition, according to the present invention, the screening method can provide signaling peptide ligand including: a sequence which has one trans-membrane domain (i); a signal peptide sequence (ii); and a sequence which does not have a functional domain (iii).