A method for predicting the risk of developing pre-eclampsia and its severity on genetic data

摘要

Risk prediction method of pre-eclampsia and its degree of severity in females Russian nationality, natives Central Chernozemya comprising blood sampling, characterized in that the DNA is isolated from peripheral venous blood by analyzing the genetic polymorphisms + 46G / A ADRB2, 4a / 4b eNOS, G460W ADD1 K198N and ET-1 and predict increased risk of developing pre-eclampsia in the presence of the allele 198K ET-1; increased risk of developing preeclampsia, moderate and severe levels of severity in the presence of a combination of genetic variants with 4a4a eNOS 198N ET-1; increased risk of developing preeclampsia, moderate and severe degrees of severity in the presence of a genotype 460WW ADD1; lower risk of preeclampsia in the presence of combinations of genetic variants + 46A ADRB2, 198N ET-1, 4b eNOS; 4b eNOS, 198N ET-1, + 46A ADRB2, 460G ADD; 198N ET-1, + 46A ADRB2, 460G ADD1; 4b eNOS, 460G ADD1, 198N ET-1; + 46A ADRB2, 198N ET-1; 198N ET-1, 4b eNOS; low risk of developing pre-eclampsia moderate and severe levels of severity in the presence of a combination of genetic variants 4b eNOS, 460G ADD1.