Multi-locus genetic risk score predicts risk for Crohn's disease in Slovenian population

摘要

AIM: To develop a risk model for Crohn's disease(CD) based on homogeneous population.METHODS: In our study were included 160 CD patients and 209 healthy individuals from Slovenia. The association study was performed for 112 single nucleotide polymorphisms(SNPs). We generated genetic risk scores(GRS) based on the number of risk alleles using weighted additive model. Discriminatory accuracy was measured by area under ROC curve(AUC). For risk evaluation, we divided individuals according to positive and negative likelihood ratios(LR) of a test, with LR > 5 for high risk group and LR 5.54) showed significantly increased odds of developing CD(OR = 26.65, 95%CI: 11.25-63.15) compared to the individuals with the lowest risk(GRS < 4.57) which is a considerably greater risk captured than in one SNP with the highest effect size(OR = 3.24). When more than 33 SNPs were included in GRS, discriminatory ability was not improved significantly; AUC of all 74 SNPs was 0.76.CONCLUSION: The authors proved the possibility of building accurate genetic risk score based on 33 risk variants on Slovenian CD patients which may serve as a screening tool in the targeted population.