首页> 外国专利> METHODS FOR TREATING PSORIATIC ARTHRITIS (PSA) USING IL-17 ANTAGONISTS AND PSA RESPONSE ALLELEES OR NO PSA RESPONSE

METHODS FOR TREATING PSORIATIC ARTHRITIS (PSA) USING IL-17 ANTAGONISTS AND PSA RESPONSE ALLELEES OR NO PSA RESPONSE

机译:使用IL-17拮抗剂和PSA反应等位基因或无PSA反应治疗脂蛋白性关节炎(PSA)的方法

摘要

1. A method for the selective treatment of a patient having psoriatic arthritis (PsA), comprising: a) selectively administering a therapeutically effective amount of an IL-17 antagonist to a patient based on the fact that the patient has an allele in the HLA-DRB1 * 04 allelic group, has an rs4263839 or does not have the rs240993 absence response allele; or b) selectively administering a therapeutically effective amount of another agent for treating PsA to a patient based on the fact that the patient does not have an rs240993 lack of allele, has an allele in the HLA-DRB1 * 04 allele group, or has an rs4263839.2 response allele. The method of claim 1, wherein the other agent for treating PsA is selected from the group consisting of NSAIDs, a TNF-alpha antagonist, sulfasalazine, methotrexate, a corticosteroid, and combinations thereof. A method for selectively treating a patient having PsA with an IL-17 antagonist, comprising: a) selecting a patient for treatment with an IL-17 antagonist based on the fact that the patient has an allele in the HLA-DRB1 * 04 allelic group, has an rs4263839 response allele, or does not have an allele lack of response rs240993; and b) then selectively administering a therapeutically effective amount of an IL-17 antagonist to the patient. The method of claim 3, further comprising: analyzing the biological sample from the patient for the presence of an allele in the HLA-DRB1 * 04 allele group, an rs4263839 response allele, or an rs240993 non-response allele, in which the analysis step is carried out prior to the selection step. The method of claim 4, wherein the analysis step comprises analyzing a biological sample for a product that is a nucleic acid, an allele in the HLA-DRB1 * 04 allele group, an rs4263839 response allele, or an rs240993 non-response allele, on an allele polypeptide product in the HLA-DRB1 allele group * 04, response allele rs4263839 or all�
机译:1.一种选择性治疗患有银屑病关节炎(PsA)的患者的方法,包括:a)基于患者在HLA中具有等位基因的事实,选择性地向患者施用治疗有效量的IL-17拮抗剂。 -DRB1 * 04等位基因组,具有rs4263839或不具有rs240993缺失反应等位基因;或b)根据患者没有rs240993等位基因缺失,HLA-DRB1 * 04等位基因组中的等位基因或患者具有以下事实,选择性地向患者选择性地施用治疗有效量的其他PsA药物: rs4263839.2反应等位基因。 3.根据权利要求1所述的方法,其中所述用于治疗PsA的其他药剂选自NSAID,TNF-α拮抗剂,柳氮磺吡啶,氨甲蝶呤,皮质类固醇及其组合。一种用IL-17拮抗剂选择性治疗患有PsA的患者的方法,包括:a)基于患者具有HLA-DRB1 * 04等位基因组中的等位基因的事实,选择要用IL-17拮抗剂治疗的患者。 ,具有rs4263839响应等位基因,或没有缺少响应rs240993的等位基因;并且b)然后选择性地向患者施用治疗有效量的IL-17拮抗剂。 4.根据权利要求3所述的方法,其进一步包括:分析来自所述患者的所述生物样品中HLA-DRB1 * 04等位基因组,rs4263839应答等位基因或rs240993无应答等位基因的等位基因的存在,其中所述分析步骤在选择步骤之前执行。 5.根据权利要求4所述的方法,其中,所述分析步骤包括对以下产品的生物样品进行分析:核酸,HLA-DRB1 * 04等位基因组中的等位基因,rs4263839应答等位基因或rs240993无应答等位基因。 HLA-DRB1等位基因组* 04中的等位基因多肽产物,应答等位基因rs4263839或全部。

著录项

  • 公开/公告号RU2014125071A

    专利类型

  • 公开/公告日2015-12-27

    原文格式PDF

  • 申请/专利权人 НОВАРТИС АГ (CH);

    申请/专利号RU20140125071

  • 发明设计人 ВАН ИН (US);

    申请日2012-06-07

  • 分类号C12Q1/68;

  • 国家 RU

  • 入库时间 2022-08-21 14:11:27

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