SODIUM DESOXYRIBONUCLEATE SUPPOSITORIES, RECTAL AND VAGINAL

摘要

1. A pharmaceutical composition in the form of a suppository, rectal or vaginal, characterized in that it contains the deoxyribonucleic acid sodium salt and the lipophilic base as the active substance, comprising cocoa butter or cocoa butter alloys with paraffin or wax, or hydrogenated fat, or plant and animal hydrogenated fats, or solid fat in the form of a mixture of mono-, di- and triglycerides of lauric acid, or lanol, or alloys of hydrogenated fats with wax or hard paraffin otherwise in the following ratio of components, mass. %: 2. The composition according to claim 1, characterized in that the base contains an alloy of cocoa butter with paraffin, where the proportion of paraffin in the mixture is 30-35% by weight. A method for producing a pharmaceutical composition in the form of a suppository, rectal or vaginal according to claim 1 or 2, characterized in that the lipophilic base is melted in a container equipped with a water jacket and a mixing device to a homogeneous mass at a temperature of 55-65 ° C with constant stirring, cooled to a temperature of 34-36 ° C, add the active substance, homogenized with a colloid mill to a homogeneous state at a temperature of 40-42 ° C, cooled to a temperature of 34-36 ° C, followed by filling with a dispenser Scientists mixture contour packaging cells, which are cooled to room temperature in the chilling tunnel.