METHOD OF OBTAINING DERIVATIVES OF 5,6-DIHYDROPYRROLO2,1-aISOQUINOLINES, WHICH CONTAIN FUNCTIONAL GROUP IN POSITION 2

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to novel method for synthesis of derivatives of 5,6-dihydropyrrolo[2,1-a]isoquinolines, which contain functional group in position 2. Method consists in the fact that 6,7-diethoxy-3,4-dihydro-1-(3,4-diethoxybenzoyl)isoquinoline is dissolved in trifluorethanol with further addition of acrolein, or croton aldehyde, or cinnamon aldehyde, or acrylonitrile and mixing at temperature +70°C, residue, obtained after reaction completion and removal of reagents, is crystallised in mixture of ether with hexane. , 1 R=H, X=CHO; R=CH₃, X=CHO; R=C₆H₅, X=CHO; R=H, X=CN.;EFFECT: increase of prime yield.;4 ex