METHOD OF PRODUCING 5,6-DIHYDROPYRROLO2,1-aISOQUINOLINE DERIVATIVES

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to a method of producing 5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives 1-4 having the general structural formula: , where 1 - R=CH₃, 2 - R=CH₂CH₃, 3 - R=CH₂CF₃, 4 - R=CH(CH₃)₂, characterised by that 6,7-diethoxy-3,4-dihydro-1-(3,4-diethoxybenzoyl)isoquinoline is mixed with methyl propiolate and methane, or ethanol, or 2,2,2-trifluoroethanol, or isopropanol and stirred at temperature of +50°C, the precipitate obtained at the end of the reaction and after removing reagents, is crystallised in ether.;EFFECT: method of producing derivatives which can be used as intermediate compounds when producing biologically active compounds.;4 ex