Efficient Synthesis of Pyrrolo2,1-aisoquinoline and Pyrrolo1,2-aquinoline Derivatives via One-pot Two- step Metal-catalyzed Three-component Reactions

摘要

A sequential one-pot two-step reaction for efficient synthesis of pyrrolo[2,1-a]isoquinoline and pyrrolo[1,2-a]- quinoline derivatives in good yields has been successfully developed. The reaction included firstly Cu-catalyzed three-component reaction of isoquinoline （quinoline）, acetylenedicarboxylate and alkynylbenzene and then Pd-catalyzed intramolecular C（sp）-C（sp^2） coupling reaction of initially formed 1-alkenyl-2-alkynyl- 1,2-dihydroiso- quinoline （1,2-dihydroquinoline）.