SOLID FORMS OF TRANSTHYRETIN DISSOCIATION INHIBITOR

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to a crystalline form of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole meglumine, wherein said crystalline form has a powder X-ray diffraction pattern comprising peaks at diffraction angles (2θ) 10.7 ± 0.2, 11.8 ± 0.2, 13.3 ± 0.2, 14.8 ± 0.2, 17.9 ± 0.2, 21.4 ± 0.2 and 21.7 ± 0.2. Invention also relates to a pharmaceutical composition that inhibits dissociation of TTR, comprising a therapeutically effective amount of said crystalline form and to a method for treatment of transthyretin-mediated amyloidosis in a mammal.;EFFECT: technical result is a crystalline form 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole meglumine having improved process properties, in particular improved stability.;8 cl, 24 dwg, 3 ex