Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies

摘要

The present invention describes the use of trifunctional bispecific antibodies for the preparation of a pharmaceutical composition for the prophylaxis and treatment of tumor diseases. It has been found that said trifunctional bispecific antibodies are binding to tumor associated antigens selected from Her2/neu, CD20, EpCAM, G250, proteoglycans, GD3, GD2, MHC II, EGF-R and CEA, wherein said tumor associated antigens are expressed on said tumor cell with a low to medium expression level only.