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Targeting EpCAM by a Bispecific Trifunctional Antibody Exerts Profound Cytotoxic Efficacy in Germ Cell Tumor Cell Lines

机译：通过双特异性三官能抗体靶向EPCAM在胚芽细胞肿瘤细胞系中发挥深刻的细胞毒性功效

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Stefan Schönberger; Daniela Kraft; Daniel Nettersheim; Hubert Schorle; Anna Casati; Rogerio B. Craveiro; Mahsa Mir Mohseni; Gabriele Calaminus; Dagmar Dilloo;
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1. Basic Science Ovarian Cancer Solitomab, an EpCAM/CD3 bispecific antibody (BITE), is highly active against primary chemotherapy resistant ovarian cancer cell lines in vitro and fresh tumor cells ex vivo [J] . English Diana P., Bellone Stefania, Schwab Carlton L., Gynecologic Oncology: An International Journal . 2015,第2期

机译：基础科学卵巢癌Solitomab，EpCAM / CD3双特异性抗体（BITE），在体外和原代新鲜肿瘤细胞中对原发性化疗耐药性卵巢癌细胞系具有高活性
2. Brentuximab vedotin exerts profound antiproliferative and pro‐apoptotic efficacy in CD30‐positive as well as cocultured CD30‐negative germ cell tumour cell lines [J] . Stefan Sch?nberger, Cornelius van Beekum, Barbara G?tz, Journal of cellular and molecular medicine. . 2018,第1期

机译：Brentuximab vedotin在CD30阳性以及共培养的CD30阴性生殖细胞肿瘤细胞系中发挥着深远的抗增殖和促凋亡作用
3. Brentuximab vedotin exerts profound antiproliferative and pro‐apoptotic efficacy in CD30‐positive as well as cocultured CD30‐negative germ cell tumour cell lines [J] . Stefan Sch?nberger, Cornelius van Beekum, Barbara G?tz, Journal of cellular and molecular medicine. . 2018,第1期

机译：Brentuximab vedotin在CD30阳性以及共培养的CD30阴性生殖细胞肿瘤细胞系中发挥着深远的抗增殖和促凋亡作用
4. A Bispecific Antibody Based on Heterodimeric Fc Demonstrates Potent Anti-Tumor Efficacy by Targeting Met and VEGFR-2 Simultaneously [C] . Ye-Jin Kim, Hye-Ji Choi, Yong-Sung Kim PEGS . 2014

机译：基于异二聚体Fc的双特异性抗体通过同时靶向满足和VEGFR-2来证明有效的抗肿瘤效果
5. Characterization of Mechanism(s) of Anti-Tumor Growth Exerted by Eosinophilic Cell Lines on Breast Tumor Cell Lines [D] . Laniyan, Ibrahim 2010

机译：嗜酸性细胞系对乳腺癌细胞系的抗肿瘤生长机制的表征
6. Targeting EpCAM by a Bispecific Trifunctional Antibody Exerts Profound Cytotoxic Efficacy in Germ Cell Tumor Cell Lines [O] . Stefan Schönberger, Daniela Kraft, Daniel Nettersheim, 2020

机译：靶向EpCAM的双特异性三功能抗体在生殖细胞肿瘤细胞系中具有深远的细胞毒功效。
7. Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells. [O] . Gilliland, LK, Clark, MR, Waldmann, H 1988

机译：通用双特异性抗体，可靶向肿瘤细胞以被细胞毒性T细胞破坏。

Targeting EpCAM by a Bispecific Trifunctional Antibody Exerts Profound Cytotoxic Efficacy in Germ Cell Tumor Cell Lines

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