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Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
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机译:阻断与CTLA-4信号相关的T淋巴细胞下调
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摘要
T Cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is released from inhibition. Such an enhanced response is useful for the treatment of tumors, chronic viral infections, and as an adjuvant during immunization.
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