MITOGEN-ACTIVATED PROTEIN KINASE-DEPENDENT RECOMBINANT VACCINIA VIRUS (MD-RVV) AND USE THEREOF

摘要

This invention provides a vaccinia virus that grows specifically in a cancer cell and damages such cancer cell and the use of such virus for treatment of cancer. Such mitogen-activated protein kinase-dependent vaccinia virus strain lacks functions of vaccinia virus growth factor (VGF) and O1L, it does not grow in normal cells but grows specifically in cancer cells, and it has oncolytic properties that specifically damage cancer cells.