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FUSION PROTEIN COMPRISING CIRCULARLY PERMUTED FORM OF TRAIL/APO2L, CODING GENE AND USE THEREOF
FUSION PROTEIN COMPRISING CIRCULARLY PERMUTED FORM OF TRAIL/APO2L, CODING GENE AND USE THEREOF
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机译:包含循环填充形式的TRAIL / APO2L,编码基因的融合蛋白及其用途
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摘要
Provided is a fusion protein comprising circularly permuted form of TRAIL, and the fusion protein contains circularly permuted form of TRAIL and oligopeptides located at the N-terminus and/or C-terminus of the permuted form. The oligopeptides contain a repeating sequence consisting of 3-10 histidines. The components of the circularly permuted form of TRAIL from N-terminus to C-terminus are: (a) amino acids 135-281 of TRAIL, (b) a linker, and (c) amino acids 121-135 of TRAIL or amino acids 114-135 of TRAIL or amino acids 95-135 of TRAIL or any fragments of amino acids 95-135 of TRAIL containing amino acids 121-135 of TRAIL. Also provided is a method for treating cancer by using the fusion protein.
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