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TARGETING APTAMER FOR ATHEROSCLEROSIS AND PREPARATION METHOD AND APPLICATION THEREOF
TARGETING APTAMER FOR ATHEROSCLEROSIS AND PREPARATION METHOD AND APPLICATION THEREOF
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机译:动脉粥样硬化的靶向剂及其制备方法和应用
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摘要
Disclosed are a targeting aptamer for atherosclerosis and a preparation method and application thereof. The targeting aptamer is a targeting aptamer fragment for atherosclerosis obtained through screening of macrophage-derived foam cells together with reverse screening of smooth muscle cells, endothelial cells, and THP-1 cells using a SELEX method; and the use of the targeting aptamer in preparation of an MRI targeting nano-contrast agent for atherosclerosis allows the specific binding of the MRI targeting nano-contrast agent for atherosclerosis only with the macrophage-derived foam cells, and allows high specific binding thereof with vascular tissues with AS lesion, thus improving targeting effect of the MRI targeting nano-contrast agent for atherosclerosis and realizing early specific diagnosis of arterial sclerosis.
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