A system to produce and validate weighted relations between drugs and adverse drug reactions ADRs, the system comprising: a public data monitoring module to monitor social media for links between drugs and ADRs; a knowledge extraction module to extract a relation between a drug and an ADR using named entity recognition and to provide a weighted relation between the drug and the ADR, the weight based on confidence of the link between the drug and the ADR in the social media; a local knowledge base to store the relation with its weight; a relation refinement module using domain knowledge in an ontology database to refine the weighted social media relation in accordance with one or more ontologies of drug names and/or of ADR symptoms; a quantification ADR module to further quantify the weighted social media relation by using drugs and ADR links extracted from research publications and/or from clinical trial reports and providing a research weight for the relation; and/or to quantify the weighted social media relation by using an internet search engine and searching for the drug and the ADR, numbers of hits quantifying an internet weight for the relation.
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