A system to produce validated weighted relations between drugs and adverse drug reactions (ADRs). At least one processor to monitor social media for links between drugs and ADRs; extract a relation between a drug and an ADR using named entity recognition to provide a weighted relation between the drug and the ADR, the weight based on confidence of the link between the drug and the ADR in social media. The at least one processor to use domain knowledge of ontologies of drug names and/or ADRs to refine the weighted social media relation; quantify the weighted social media relation by using drugs and ADR links extracted from research publications and/or from clinical trial reports and provide a research weight for the relation; and/or quantify the weighted social media relation by using internet search engine and searching for the drug and the ADR, numbers of hits quantify internet weight for the relation.
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