METHOD OF FORMING ORGAN HAVING THREE-DIMENSIONAL VASCULAR NETWORK IN VIVO AND COMPOSITION FOR FORMING ORGAN HAVING THREE-DIMENSIONAL VASCULAR NETWORK

摘要

PROBLEM TO BE SOLVED: To provide a technique for forming an organ having a three-dimensional vascular network, which is necessary for constructing a transplantable-regenerating organ.SOLUTION: According to the present invention, there is provided a method for forming an organ having a three-dimensional vascular network in vivo in a non-human animal. The method comprises the steps of: (a) in a non-human animal, arranging one or more blood vessels to allow the blood vessels to penetrate a structure while being connected to the living body, or, after arranging one or more isolated blood vessels to allow the blood vessels to penetrate the structure, connecting "the one or more isolated blood vessels" to blood vessels in the living body, the structure being configured to have a hollow therein and containing organ buds; and (b) forming an organ having a three-dimensional vascular network in the hollow inside the structure by culturing in vivo the organ buds contained inside the blood vessels and the structure in the inside of the structure.SELECTED DRAWING: None