In this paper, we constructed 3D hepatic lobule-like structure in 3D cellular structure. Without perfusable channel networks, 3D cellular structure more than 200 µm cannot keep the cells in core of the structure in living condition. To construct mm-sized cellular structure, well-organized vascular network is required. For this, we proposed a method to construct hepatic lobule like vascular network. Two types of steel rods and alginate gel fiber embedding magnetic particles were utilized to make a shape of the hepatic tissue. It has a hexagonal structure and consists of several veins. To realize portal veins and a central vein, 0.4 mm and 0.2 mm of steel rods were used, respectively. In addition, sinusoids were replaced by 0.15 mm magnetic fibers. By using these materials, we construct 3D hepatic tissue with similar size of the real things. In addition, we perfused nutrients to the cells through channels. Finally, we constructed 3D perfusable vascular network that mimics hepatic lobule tissues.
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