Innovative bottom-up cell assembly approach to three-dimensional tissue formation using nano-or micro-fibers

摘要

The present invention provides a synthetic tissue scaffold, the scaffold comprising alternating layers of electrospun polymers and mammalian cells sandwiched within. A novel method is also provided for generating a three-dimensional tissue by electrospinning polymers and seeding cells in alternating layers on an aqueous solution in a desired shape. This invention is suitable for generating animal tissue as well as for delivery of drugs or other substances to a recipient.