IMPROVED AMINO ACID SEQUENCES DIRECTED AGAINST HUMAN RESPIRATORY SYNCYTIAL VIRUS (HRSV) FOR PREVENTING AND/OR TREATING RESPIRATORY TRACT INFECTIONS AND POLYPEPTIDES COMPRISING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide polypeptides comprising amino acid sequences directed against and/or capable of specifically binding to protein F of hRSV (human respiratory syncytial virus).SOLUTION: The invention provides a polypeptide comprising or essentially consisting of at least one amino acid sequence or Nanobody(R) that is directed against and/or specifically binds to protein F of hRSV, where the amino acid sequence or Nanobody(R) comprises one or more amino acid sequences selected from: a) specified 17 amino acid sequences, b) amino acid sequences having no more than 3, preferably no more than 2, more preferably no more than 1 amino acid difference with the specified 17 amino acid sequences. The amino acid sequence may have glutamine (Gln, Q) at position 105 (the position determined according to Kabat numbering).SELECTED DRAWING: None