Crystal structure of human 4-phosphate adapter protein 2 glycolipid transfer protein-like domain

摘要

In some embodiments, the invention provides a method of identifying a compound that binds to phosphoinositol 4-phosphate adapter protein-2 (FAPP2), wherein the atomic coordinates of at least amino acids that constitute the substrate binding pocket of FAPP2 Use to provide a method comprising the step of computationally identifying a compound that binds to FAPP2. Also provided are methods for designing, selecting and / or optimizing compounds that bind to FAPP2. In one aspect, a method is provided for identifying a compound that binds to phosphoinositol 4-phosphate adapter protein-2 (FAPP2), the method comprising at least the amino acids of the FAPP2 substrate binding pocket shown in Table 2. Computer identification of compounds that bind to FAPP2 using atomic coordinates.