ANTICANCER DRUG ON CANCER STEM CELL USING EXPERIMENTAL ANIMAL AND RADIATION SENSITIVITY TESTING METHOD

摘要

PROBLEM TO BE SOLVED: To provide an anticancer drug on cancer stem cells using an experimental animal and a radiation sensitivity testing method.;SOLUTION: Cancer stem cells derived from cancer tissues of human or other mammals are separated and extracted by an expression of a cancer stem cell surface marker, an ALDEFLUOR method or a coloring degree of a Hoechst 33342DNA fluorescent pigment. Then, the cancer stem cells are transplanted into an experimental animal not treated or previously administered with the anticancer drug, thereby determining cytocidal effect toward the cancer stem cells or a human cancer cell population including the stem cancer cells by administering the cancer drug or radiation irradiation or using both the administration of the cancer drug and the radiation irradiation simultaneously or once or more than once after a prescribed time .;SELECTED DRAWING: Figure 1;COPYRIGHT: (C)2017,JPO&INPIT