Peripheral focal GABA positive allosteric modulator for the treatment of irritable bowel syndrome and other diseases of the peripheral nervous system

摘要

The present invention provides compounds and compositions that are positive allosteric modulators of GABA-A receptors that selectively target the peripheral nervous system and organs of the body and do not cross the blood brain barrier. The compounds and compositions of the present invention may include, for example, visceral pain, bowel motility, irritable bowel syndrome, functional abdominal pain, functional idiopathic diarrhea, inflammatory bowel disease, drug-induced pain, bile salt malabsorption, lactase or Useful for the treatment of diseases or disorders mediated by GABA-A neuronal activity, such as other carbohydrate intolerances.