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Simultaneously integrated selection and evolution of antibody / protein performance and expression in the production host
Simultaneously integrated selection and evolution of antibody / protein performance and expression in the production host
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机译:在生产宿主中同时整合抗体/蛋白质性能和表达的选择和进化
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摘要
The present disclosure provides methods of integrating therapeutic protein and antibody generation and/or selection, evolution and expression in a eukaryotic host for manufacturing in a single system. Therapeutic proteins, including antibodies, are generated, optimized and manufactured in the same eukaryotic host system. The disclosed system of Comprehensive Integrated Antibody Optimization (CIAO!„¢) allows for simultaneous evolution of protein performance and expression optimization.
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