The present application provides methods for integrating therapeutic protein and antibody production and/or selection, evolution, and expression in a eukaryotic host to produce in a single system. Therapeutic proteins, including antibodies, are produced, optimized and prepared in the same eukaryotic host system. The described system of Comprehensive Integrated Antibody Optimization (CIAO! ™ ) allows for the simultaneous evolution of protein performance and expression optimization.
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