首页> 外国专利> NERVE CELL DEATH INHIBITOR, ANTI-ALZHEIMER'S DISEASE AGENT, BRAIN HYPOFUNCTION INHIBITOR, DRUG OR FOOD HAVING ANTI-ALZHEIMER'S DISEASE EFFECT OR BRAIN HYPOFUNCTION-INHIBITING EFFECT, AND METHOD FOR PRODUCING NERVE CELL DEATH INHIBITOR

NERVE CELL DEATH INHIBITOR, ANTI-ALZHEIMER'S DISEASE AGENT, BRAIN HYPOFUNCTION INHIBITOR, DRUG OR FOOD HAVING ANTI-ALZHEIMER'S DISEASE EFFECT OR BRAIN HYPOFUNCTION-INHIBITING EFFECT, AND METHOD FOR PRODUCING NERVE CELL DEATH INHIBITOR

机译:神经细胞死亡抑制剂,抗老年痴呆症药物,脑功能低下抑制剂,药物或食物具有抗老年痴呆症或抑制脑功能低下的作用以及产生神经细胞死亡的方法

摘要

A nerve cell death inhibitor, an anti-Alzheimer's disease agent, a brain hypofunction inhibitor and a drug or food having an anti-Alzheimer's disease effect or a brain hypofunction-inhibiting effect, each containing as an active ingredient "a preset partitioned portion that is a portion partitioned in methylene dichloride when an ethanol extract of Rhinacanthus nasuta (L.) Kurz is liquid-liquid partitioned with hexane and methanol and then the portion partitioned in methanol is liquid-liquid partitioned with methylene dichloride and water", "a preset fraction that is a fraction eluted from a silica gel column with an elution solvent, said elution solvent consisting of n-hexane, ethyl acetate and anhydrous methanol, when the preset partitioned portion is subjected to silica gel column chromatography using the elution solvent" or Rhinacanthin C. According to the present invention, a nerve cell death inhibitor having an excellent effect of inhibiting nerve cell death, an anti-Alzheimer's disease agent, a brain hypofunction inhibitor and a drug or food having an anti-Alzheimer's disease effect or a brain hypofunction-inhibiting effect can be provided.
机译:神经细胞死亡抑制剂,抗阿尔茨海默氏病药剂,脑功能低下抑制剂以及具有抗阿尔茨海默氏病作用或抑制脑功能低下作用的药物或食品,它们各自包含作为活性成分的“预先设定的部分当Rhinacanthus nasuta(L.)Kurz的乙醇提取液与己烷和甲醇进行液-液分配,然后在甲醇中分配的部分与二氯甲烷和水液-液分配时,一部分分配在二氯甲烷中。这是用洗脱溶剂从硅胶柱上洗脱的馏分,当使用洗脱溶剂或Rinacanthin C对预设的分配部分进行硅胶柱色谱分析时,所述洗脱溶剂由正己烷,乙酸乙酯和无水甲醇组成根据本发明,具有优异的抑制神经细胞死亡作用的神经细胞死亡抑制剂,抗阿尔茨海默氏病。可以提供具有抗阿尔茨海默氏病作用或抑制脑功能低下的作用的抗病剂,脑功能低下的抑制剂和药物或食品。

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