Stable maintenance of stem cells, the use of peptidyl prolyl isomerase Pin1 to control replication

摘要

Establishing induced pluripotent stem of stable (iPS) cells with high efficiency, to provide a method which enables maintenance and replication. Method comprising the step of enhancing the expression of the peptidyl prolyl isomerase Pin1 in somatic cells to produce induced pluripotent stem cells from somatic cells. Induced pluripotent stem cells that have been produced by the method. Of pluripotent stem cells and agents that activate including the peptidyl prolyl isomerase Pin1 and substance enhances the expression of the peptidyl prolyl isomerase Pin1 in somatic cells and / or, a self-replicating somatic cell reprogramming accelerator, of pluripotent stem cells drug to maintain pluripotency. Inhibit drug contains a substance that inhibits the peptidyl prolyl isomerase Pin1, a self-replicating of pluripotent stem cells, agents that disrupt the pluripotency of pluripotent stem cells, and I kill the cancer stem cells and pluripotent stem cells and / or drug. Including the Pin1 gene and / or peptidyl prolyl isomerase Pin1, transcriptional activity enhancer of Oct4 protein and stabilizing agent of Oct4 protein.