Resistance mutant 90 kDa heat shock protein

摘要

An object of the present invention is to identify a patient who is resistant to a known HSP90 inhibitor and to provide a new therapeutic agent for treating a patient who has become resistant to a known HSP90 inhibitor. As a means for solving the above problems, the present invention identifies a patient based on a protein having a mutation at a site corresponding to F138 of HSP90α class A consisting of the amino acid sequence of SEQ ID NO: 1, which is an HSP90 family protein, It is provided that a substance that inhibits is used as an active ingredient of a therapeutic agent.