首页>
外国专利>
Resistance mutant 90 kDa heat shock protein
Resistance mutant 90 kDa heat shock protein
展开▼
机译:抗性突变体90 kDa热激蛋白
展开▼
页面导航
摘要
著录项
相似文献
摘要
An object to be solved by the present invention is to identify patients resistant to known HSP90 inhibitors, and to provide a novel therapeutic agent for treating the patients who have become resistant to known HSP90 inhibitors. As a means for solving the above problems, the present invention provides identification of the patients based on a protein, which is an HSP90 family protein having a mutation in the site corresponding to F138 of HSP90± class A consisting of the amino acid sequence of SEQ ID NO: 1, and use of a substance that inhibits the protein as an active ingredient of a therapeutic agent.
展开▼
机译:本发明要解决的目的是鉴定对已知的HSP90抑制剂有抗药性的患者,并提供一种新颖的治疗剂,用于治疗对已知的HSP90抑制剂有抗药性的患者。作为解决上述问题的手段,本发明基于蛋白质来鉴定患者,所述蛋白质是在对应于由SEQ ID NO:1的氨基酸序列组成的HSP90±A类的F138的位点具有突变的HSP90家族蛋白。 ID ID:1,以及抑制蛋白质的物质作为治疗剂的活性成分的用途。
展开▼