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Human Cystathionine Beta-Synthase Variants and Methods of Production Thereof
Human Cystathionine Beta-Synthase Variants and Methods of Production Thereof
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机译:人胱硫醚β合酶变体及其生产方法
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摘要
Human cystathionine β-synthase variants are disclosed, as well as a method to produce recombinant human cystathionine β-synthase and variants thereof. More particularly, the role of both the N-terminal and C-terminal regions of human CBS has been studied, and a variety of truncation mutants and modified CBS homologues are described. In addition, a method to express and purify recombinant human cystathionine β-synthase (CBS) and variants thereof which have only one or two additional amino acid residues at the N-terminus are described.
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