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Treatment of Paraoxonase 1 (PON1) related diseases by inhibition of natural antisense transcript to PON1

机译：通过抑制PON1的天然反义转录本来治疗对氧磷酶1（PON1）相关疾病

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摘要

The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Paraoxonase 1 (PON1), in particular, by targeting material antisense polynucleotides of Paraoxonase 1 (PON1). The invention also relates to the identification of these antisense oligonucleoties and their use in treating diseases and disorders associated with the expression of PON1.

机译：本发明涉及反义寡核苷酸，其特别是通过靶向对氧磷酶1（PON1）的材料反义多核苷酸来调节对氧磷酶1（PON1）的表达和/或功能。本发明还涉及这些反义寡核苷酸的鉴定及其在治疗与PON1表达有关的疾病和病症中的用途。

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公开/公告号US9714423B2

专利类型
公开/公告日2017-07-25

原文格式PDF
申请/专利权人 CURNA INC.;
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申请/专利号US201414579406
发明设计人 JOSEPH COLLARD;OLGA KHORKOVA SHERMAN;
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申请日2014-12-22
分类号A61K48;C12N15/11;C07H21/02;C07H21/04;C12N15/113;A61K31/713;
国家 US
入库时间 2022-08-21 13:45:00

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