1 11 TREATMENT OF PARAOXONASE 1 PON1 RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO PON1

摘要

The present invention relates to antisense oligonucleotides that modulate the expression and / or function of paraoxonase 1 (PON1), particularly antisense oligonucleotides targeted to natural antisense polynucleotides of paraoxonase 1 (PON1). The present invention also relates to the identification of such antisense oligonucleotides and to their use in the treatment of diseases and disorders associated with the expression of PONl.