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Combinations of corroles and statins

机译:rol和他汀类药物的组合

摘要

Embodiments of the invention relate to methods of treatment a cardiovascular disease in a patient comprising administering an effective amount of a statin or a pharmaceutically acceptable salt thereof in combination with an effective amount of a transition metal complex of a corrole, an optically active isomer thereof or a pharmaceutically acceptable salt thereof. Further embodiments refer to pharmaceutical compositions comprising a statin and a corrole. Optionally, the corrole has a structure:; embedded image wherein;M is a transition metal selected from the group consisting of Mn, Fe, Ru, Co, V, Cr, and Cu and R1, R2, R3, X1, X2, X3X4; E2, E3, E17 and E18 are each defined as in the specification.
机译:本发明的实施方案涉及治疗患者的心血管疾病的方法,其包括与有效量的他汀,其旋光异构体或其药学上可接受的盐。进一步的实施方案涉及包含他汀类药物和Corrole的药物组合物。任选地,该corrole具有以下结构: “嵌入式图像” 其中;M是选自Mn,Fe,Ru,Co,V,Cr和Cu以及R 1 ,R 2 ,R 的过渡金属。 3 ,X 1 ,X 2 ,X 3 X 4 ; E 2 ,E 3 ,E 17 和E 18 均按规范定义。

著录项

  • 公开/公告号US9642860B2

    专利类型

  • 公开/公告日2017-05-09

    原文格式PDF

  • 申请/专利权人 ZEEV GROSS;MICHAEL AVIRAM;ADI HABER;

    申请/专利号US201214238756

  • 发明设计人 ZEEV GROSS;MICHAEL AVIRAM;ADI HABER;

    申请日2012-08-14

  • 分类号C07D487/22;A61K31/555;A61K45/06;A61K31/22;A61K31/366;A61K31/40;A61K31/404;A61K31/4418;A61K31/47;A61K31/505;A61K31/405;

  • 国家 US

  • 入库时间 2022-08-21 13:42:24

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