Protein icos Union or Union of the portion of the same antigen, monoclonal antibody of the same and Pharmaceutical composition containing same

摘要

A Union to icos Protein or Antigen binding portion of which is an agonist for Human icos and induces complement, ADCC or CDC When placed in contact with a T Lymphocyte in vivo and application in Methods of treatment of cancer, infectious diseases and / or sepsis with The icos Binding Protein or a portion of the same Antigen Binding.In addition, the Union to icos Protein or Antigen binding portions thereof are capable of activating a T Lymphocyte When placed in contact with the T Lymphocyte; stimulate the Proliferation of T lymphocytes when in contact with the T Lymphocyte and / or induce the produ Action of cytokines when in contact with the T Lymphocyte.The Union to icos Protein or Antigen binding portions thereof comprise of one or more of: SEC sec id id no. 1, no. 2; SEC sec id id no. 3, no. 4; SEC ID no. 5; and / or SEC ID no. 6.