Human monoclonal antibody or antigen-binding portion thereof that specifically binds to IGF-IR, pharmaceutical composition comprising the antibody or antigen-binding portion thereof, isolated cell line producing the antibody, isolated nucleic acid molecule, vector, host cell, transgenic animal, method of making of antibody or antigen-binding portion thereof and use of the antibody and the isolated nucleic acid molecule

摘要

Described is a human monoclonal antibody or antigen-binding portion thereof that specifically binds to insulin-like growth factor I receptor (IGF-IR), wherein said antibody or portion inhibits the binding of IGF-I or IGF-II to IGF-IR and inhibits tumor growth in-vivo; a pharmaceutical composition comprising thereof; an isolated cell line producing the antibody; an isolated nucleic acid molecule, that encodes a heavy chain or an antigen-binding portion thereof or a light chain or an antigen-binding portion thereof of an antibody; a vector comprising the nucleic acid molecule; a host cell; a non-human transgenic animal; a method of making an anti-IGF-IR antibody or antigen-binding portion thereof and use of the antibody.