1,8 2,4-Diaryl-substituted naphthyridines as cancer kinase inhibitors

摘要

[1,8] 2,4-Diaryl substituted naphthyridines as kinase inhibitors for use against cancer. The present invention relates to novel [1,8] naphthyridine derivatives of formula (I) and to the use of such compounds wherein inhibition, regulation and / or signal transduction modulation by atp-consuming proteins such as kinases plays a role. particularly for tgf-beta receptor kinase inhibitors, and the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.