OXIDATION and AMINATION OF PRIMARY ALCOHOLS

摘要

patent abstract: "oxidation and amination of primary alcohols". The present invention relates to a process comprising the steps of a) preparing a primary alcohol of the formula ho - (ch2) x - r1, wherein r1 is selected from the group comprising -oh, -sh, -nh2 and -coor2, x is at least 3 and r2 is selected from the group comprising h, alkyl and aryl, b) oxidation of the primary alcohol through contact with a nad (p) -dependent alcohol dehydrogenase + and c) oxidation product contact of step a) with a transaminase, and in the case of nad (p) + and / or transaminase dependent alcohol dehydrogenase, it is a recombinant or isolated enzyme, a whole cell catalyst for the execution of the process and the use of such a whole cell catalyst for the oxidation of a primary alcohol.