Oxidation and amination of primary alcohols

摘要

Process method for the oxidation of alcohols, comprising steps a) making available a primary alcohol of the formula HO- (CH2) x-R1, R1 being selected from the group comprising -OH, -SH, -NH2 and -COOR2, where x is at least 3, and R2 being selected from the group comprising H, alkyl and aryl, b) oxidation of the primary alcohol by contacting a NAD-dependent alcohol dehydrogenase (P) +, and c) contacting the oxidation product of step a) with a transaminase, in the case of NAD (P) + - alcohol dehydrogenase and / or transaminase, a recombinant or isolated enzyme.