The process of obtaining serum antiapu00edlico horse, equine serum and its uses antiapu00edlico

摘要

The process of obtaining serum antiapu00edlico horse, equine serum antiapu00edlico and its uses, the present invention relates to the process of obtaining an equine serum antiapu00edlico against the poison of Africanized honeybees Apis mellifera, produced from the blood of horses hiperimunizados used Of himself as the major antigen fractions toxic venom of Apis mellifera (melitina and phospholipase A2).Describes the whole process of extraction of the venom, purification of fractions of interest, the preparation of the antigen, hiperimunizau00e7u00e3o horses, production of plasma hiperimune, preparation of concentrated specific antibodies and of the finished product, after its purification by filtrau00e7 Will esterelizante and clarification, filling, the final formulation, pre clinical studies, dosing, and their uses and indications.