compound, pharmaceutical composition, and methods for inhibiting romk in a patient, causing diuresis, natriuresis, or both, and for treating one or more disorders.

摘要

1/1 summary "compounding, pharmaceutical composition, and methods for inhibiting romk in a patient, causing diuresis, natriuresis or both and for treating one or more disorders" The present invention provides compounds of formula I are the pharmaceutically acceptable salts thereof which are inhibitors of the romk 1 channel (kir .1). The compounds may be used as diuretic and / or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with retention. salt and excessive water.