compound, pharmaceutical composition, and methods for inhibiting romk, causing diuresis, natriuresis or both, and treating or prophylaxis of one or more disorders

摘要

The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.