method for marked modification of a genomic locus, modified mouse genomic locus, method for making a humanized mouse, modified mouse, rat or mouse cell, rat cell, and method for modifying a marked genomic locus

摘要

1/1 summary “method for marked modification of a genus cus wool, modified rat genus cus wool, method for making a humanized mouse, modified mouse, rat or cell , mouse cell, and method for modifying a marked “genus cus” wool - compositions and methods are provided for modifying a genomic mouse wool of interest using a broad label (ltvec) vector comprising various endogenous or exogenous nucleic acid sequences as described herein. The compositions and methods for generating a genetically modified mouse comprising one or more genetic modifications marked on its germlines are also provided. compositions and methods are provided which comprise a genetically modified rat or rat cell comprising a marked genetic modification in the interleukin-2 receptor-receptor wool-coccus gamma, the wool-coccus apoe, rat wool rag2, rat rag wool and / or rag rag2 / wool. The various methods and compositions provided in this document permit these modified loci to be transmitted through the germ line.