PROCESS OF PRODUCTION AND PURIFICATION OF RECOMBINANT HYDROGEN HYDROGEN HYBRID OR NON-HYBRID, RECOMBINANT HYDROGEN HYDROGEN HYBRIDS OR NON-HYBRID, VECTORS OF EXPRESSION, AND USES OF RECOMBINANT GLICOPROTETIC HORMONES

摘要

The present invention relates to a process for the production of hormones glicoproteicos recombinant hybrids or non hybrids, for example, the recombinant equine chorionic gonadotrophin (R - ECG), chorionic gonadotropin hormone recombinant hybrid, the tireoestimulante recombinant (R - TSH ), the luteinizing hormone recombinant (R - LH), the luteinizing hormone.And the recombinant follicle stimulating hormone (R - FSH).In addition, the present invention relates to hormones glicoproteicos comprising the alpha and beta subunits in recombinant equine and others, the alpha and beta subunits of mammalian equine, where the two subunits will be merged into a single chain and chain change agents It provides greater ease of purification, homogeneity.The facility of industrial scale and without the use of animals, when compared to the wild glicoproteico hormone. In addition, the present invention relates to the use of these hormones in animal breeding assisted, ovulation induction; induction of superovulation, follicular growth; induction of estrus; reversal of anestro; induction of puberty in animals of commercial interest or not.