'human igg1 mab, specifically binding to human il-1a, isolated nucleic acid pool, method for killing a human il-1a expressing cell, method of inhibiting cell migration through a basement membrane matrix , method of inhibiting an il-1a-induced increase in e-selectin expression on the surface of a human endothelial cell and method of screening for inflammation in human patients. '

摘要

Fully human monoclonal Abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for IL-1α and (ii) a constant region that is effective at both activating the complement system though Clq binding and binding to several different Fc receptors.