Derivatives of benzamide compounds to inhibit the activity of ABL1 and BCR - ABL1, ABL2, useful in the treatment of cancer

摘要

p The present Invention relates to compounds of the formula (i): / p p Space for the formula I / p p in where, and Y1, R1, R2, R3 and R4 are defined according to the demands. The compounds of the invention are capable of inhibiting the activity of BCR - ABL1 and Mutants thereof, which are useful in the treatment of cancer, in particular chronic myeloid leukemia.The Invention also provides a process for the preparation of the compounds of the invention. / p