Formulas (I) of antagonists of CCR1 receptors are disclosed, in which X is N or C r2_AR1 is the selection of each criterion for kappa alpha____ It is used one to three ra_kappa_kappa lambda_G is circular.Or one or two______r8_R1 is hydrogen, alkyl or C1-6-___c1-___________ A composition, formula (I) compound for preparing and using the method is also disclosed.
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