NOVEL-4β-(4-SUBSTITUTED)-1,2,3-TRIAZOL-1-YL-PODOPHYLLOTOXINS AS POTENTIAL ANTICANCER AGENTS

摘要

NOVEL-4ß-[(4-SUBSTITITED)-1,2,3-TRIAZOL-1-YL]-PODOPHYLLOTOXINS A series of 4ß-[(4-substituted)-l,2.3-triazol-l-yl] podophyllotoxin congeners have been designed and synthesized with significant regioselectivity by employing Cu (I) catalyzed 1,3-dipolar cycloaddilon reaction of C-4ß-azido podophyllotoxin and C-4.ß-azido-4"-O-demethyl podophyllotoxin with aliphatic and aromatic terminal alkynes. These compounds were evaluated for anticancer activity against a panel of seven human cancer cell lines.