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4-substituted benzoic acid derivative and anticancer agent containing it as an active ingredient

机译:4-取代的苯甲酸衍生物和以其为有效成分的抗癌剂

摘要

A novel compound that does not act on normal cells and specifically transforms cells transformed by various cancer genes and provides anticancer agents containing it. General formula (I):In the equation, G1 may be either or1 or nr2r3 (where R2 and R3 are the same or different, hydrogen, lower alkyl or hydroxyl group, or R2 and R3 together form nitrogen containing heterocycles together; 3 and G4 may form G3, hydrogen, hydroxyl or low alkyl alkylcarbonyloxy, G4 is lower alkyl or g3-g4 together form g2-g5; G5 is or4 or nr5r6 Compounds or salts thereof or their hydrates represented by the formula group, R6 indicating hydrogen or lower alkyl.
机译:一种不会对正常细胞起作用的新型化合物,它可以特异性转化被多种癌症基因转化的细胞,并提供含有该化合物的抗癌药。通式(I):在等式中,G1可以是or1或nr2r3(其中R2和R3相同或不同,氢,低级烷基或羟基,或R2和R3一起形成含氮杂环; 3和G4可以形成G3,氢,羟基或低级烷基烷基羰氧基,G4为低级烷基或g3-g4一起形成g2-g5; G5为or4或nr5r6由式基团表示的化合物或其盐或水合物,R6表示氢或低级烷基。

著录项

  • 公开/公告号JPWO99/12884A1

    专利类型

  • 公开/公告日2002-08-20

    原文格式PDF

  • 申请/专利权人 塩野義製薬株式会社;

    申请/专利号JP特願2000-510697(P2000-510697)

  • 发明设计人 芳賀 展弘;杉田 憲治;鎌田 進;

    申请日1998-09-07

  • 分类号C07C65/40;A61K31/165;A61K31/19;A61K31/235;C07C69/94;

  • 国家 JP

  • 入库时间 2022-08-22 01:02:33

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