Synthesis of New Spin Labeled Derivatives of Podophyllotoxin as Potential Anticancer Agents

摘要

Five new nitroxyl spin labeled podophyllotoxins (2-6) have been synthesized.Compounds 2 and 3 have been tested for their anticancer activity in vitro. The results showed that compound 3 is much more potent than the clinically used etoposide (VP-16) in its inhibition of P388 cells, while compound 2 is not